Assessment of mesterolone therapy in oligospermic males

Objective: To study the effects of Mesterolone alone and combination of Mesterolone and Clomiphene Citrate on semen parameters, pituitary axis and liver function in Idiopathic Oligospermic males. Materials and Methods: 30 males with Idiopathic Oligospermia (sperm count < 20-million/ml) between 20-45 years of age were included in the study. Of the 30 subjects, 10 were given tab Mesterolene 50 mg b.d (Group A), 10 males were given 50 mg of tab Mesterolone 1 b.d and 25 mg of Clomiphene Citrate 1 o.d. (Group B) , 10 were used as controls and were administered placebo (Group C ) for 4 months. A follow up study was conducted at the end of 100 days, 150 days and 200 days,in groups A, B and C respectively . The patients from each group were evaluated for semen parameters, serum hormonal levels, liver function tests and percentage of conception following therapy. The following semen parameters were determined: semen volume (ml), viscosity, sperm count in million/ml, percentage of grade III motility, percentage of sperms with normal morphology, percentage of living sperms, percentage of immature sperms and differential sperm count. Results: Its was shown that the combination of Mesterolone with Clomiphene was more effective in increasing sperm count (40%) than Mesterolone alone (-31.62%) (p=0.118). Conclusion: The combination of Mesterolone with clomiphene was more effective than mesterolone.It produced an increase in sperm count (40%) compared with Mesterolone alone (-31.62 %). We have tried to formulate this new regimen of both Mesterolone and Clomiphene , which has proven to yield better results.